Recommended Citation
Yeon Paek S, Han L, Weiland M, Lu C, Maksimowicz-McKinnon K, Zhou L, Lim HW, Elder JT, Mi Q. Emerging biomarkers in psoriatic arthritis. IUBMB life 2015; 67(12):923-927.
Document Type
Article
Publication Date
12-1-2015
Publication Title
IUBMB life
Abstract
Psoriasis is an immune-mediated skin disease which affects 2-4% of the worldwide population. Approximately 20-30% of patients with psoriasis develop psoriatic arthritis (PsA), a frequently destructive and disabling condition. As skin manifestations precede joint symptoms in nearly all patients with PsA, identification of biomarkers for early prediction of joint damage is an important clinical need. Because not all patients with PsA respond to treatment in the same fashion, identification of biomarkers capable of predicting therapeutic response is also imperative. Here, we review existing literature and discuss current investigations to identify potential biomarkers for PsA disease activity, with particular emphasis on microRNAs as novel markers of interest. Serum (soluble) biomarkers, peripheral osteoclast precursor as cellular biomarkers, and genetic loci associated with skin and joint disease are also reviewed.
Medical Subject Headings
Arthritis, Psoriatic; Biomarkers; Genetic Markers; Humans; MicroRNAs; Osteoclasts; Polymorphism, Single Nucleotide
PubMed ID
26602058
Volume
67
Issue
12
First Page
923
Last Page
927
