Dupilumab for the Treatment of Chronic Actinic Dermatitis

Document Type

Article

Publication Date

4-22-2020

Publication Title

Photodermatology, photoimmunology & photomedicine

Abstract

Chronic actinic dermatitis (CAD) is an immune-mediated photodermatosis characterized by chronic, pruritic, eczematous, and often lichenified plaques distributed primarily upon sun-exposed skin.(1) The pathophysiology is believed to involve a delayed-type hypersensitivity reaction to an endogenous, photoinduced, cutaneous antigen, which has been speculated to be DNA.(1) First-line management options include strict photoprotection, topical corticosteroids (TCS), and topical calcineurin inhibitors (TCI). However, these are rarely sufficient on their own. Thus, many systemic therapies are often utilized with varying degrees of success.

PubMed ID

32320500

ePublication

ePub ahead of print

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