Dupilumab for the Treatment of Chronic Actinic Dermatitis
Patel N, Konda S, and Lim HW. Dupilumab for the Treatment of Chronic Actinic Dermatitis. Photodermatol Photoimmunol Photomed 2020.
Photodermatology, photoimmunology & photomedicine
Chronic actinic dermatitis (CAD) is an immune-mediated photodermatosis characterized by chronic, pruritic, eczematous, and often lichenified plaques distributed primarily upon sun-exposed skin.(1) The pathophysiology is believed to involve a delayed-type hypersensitivity reaction to an endogenous, photoinduced, cutaneous antigen, which has been speculated to be DNA.(1) First-line management options include strict photoprotection, topical corticosteroids (TCS), and topical calcineurin inhibitors (TCI). However, these are rarely sufficient on their own. Thus, many systemic therapies are often utilized with varying degrees of success.
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