Epidermal resident γδ T cell development and function in skin
Recommended Citation
Xu Y, Dimitrion P, Cvetkovski S, Zhou L, and Mi QS. Epidermal resident γδ T cell development and function in skin. Cell Mol Life Sci 2020.
Document Type
Article
Publication Date
8-17-2020
Publication Title
Cellular and molecular life sciences
Abstract
Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular mechanisms remain elusive. Here, we reviewed the recent research progress on DETCs, including their origin and homeostasis in the skin, especially at transcriptional and epigenetic levels, and discuss the involvement of DETCs in skin diseases.
PubMed ID
32803399
ePublication
ePub ahead of print
