Title

Epidermal resident γδ T cell development and function in skin

Document Type

Article

Publication Date

8-17-2020

Publication Title

Cellular and molecular life sciences

Abstract

Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular mechanisms remain elusive. Here, we reviewed the recent research progress on DETCs, including their origin and homeostasis in the skin, especially at transcriptional and epigenetic levels, and discuss the involvement of DETCs in skin diseases.

PubMed ID

32803399

ePublication

ePub ahead of print

Share

COinS