Insights from γ-Secretase: Functional Genetics of Hidradenitis Suppurativa

Authors

Gautham Vellaichamy, Henry Ford HealthFollow
Peter Dimitrion, Henry Ford HealthFollow
Li Zhou, Henry Ford HealthFollow
David M. Ozog, Henry Ford HealthFollow
Henry W. Lim, Henry Ford HealthFollow
Wilson Liao
Iltefat H. Hamzavi, Henry Ford HealthFollow
Qing-Sheng Mi, Henry Ford HealthFollow

Recommended Citation

Vellaichamy G, Dimitrion P, Zhou L, Ozog D, Lim HW, Liao W, Hamzavi IH, and Mi QS. Insights from γ-Secretase: Functional Genetics of Hidradenitis Suppurativa. J Invest Dermatol 2021.

Document Type

Article

Publication Date

4-6-2021

Publication Title

The Journal of investigative dermatology

Abstract

Hidradenitis suppurativa (HS) is a chronic, relapsing, and remitting inflammatory disease of the skin with significant heritability and racial disposition. The pathogenesis of HS remains enigmatic, but occlusion of the terminal hair follicle and dysregulation of the local innate immune response may contribute to pathogenesis. Genetic predisposition might also contribute to disease susceptibility and phenotypic heterogeneity because mutations in γ-secretase have been found to underlie a minor but characteristic subset of patients with HS. In this review, we synthesized the current data on γ-secretase in HS, evaluated its importance in the context of disease pathobiology, and discussed avenues of future studies.

PubMed ID

33836848

ePublication

ePub ahead of print