Current concepts in acne pathogenesis: Pathways to inflammation
Recommended Citation
Tan JK, Stein Gold LF, Alexis AF, Harper JC. Current concepts in acne pathogenesis: Pathways to inflammation. Seminars in cutaneous medicine and surgery 2018; 37(3S):S60-S62.
Document Type
Article
Publication Date
6-1-2018
Publication Title
Seminars in cutaneous medicine and surgery
Abstract
Acne is a disease of pilosebaceous inflammation. Pivotal in pathogenesis are the roles of hormones (insulin, insulin-like growth factor-1, androgens), Propionibacterium acnes, lipogenesis, and a proinflammatory lipid profile. Innate immune responses are induced through interaction with toll-like receptors and inflammasome activation initially and subsequently through adaptive immune activation. These insights into pathogenic inflammatory pathways can translate into novel therapeutic approaches for acne. Semin Cutan Med Surg 37(supp3):S60-S62 ©2018 published by Frontline Medical Communication.
PubMed ID
30192343
Volume
37
Issue
3S
First Page
S60
Last Page
S62
