Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology.

Authors

Gautham Vellaichamy, Henry Ford HealthFollow
Anya T Amin
Peter Dimitrion, Henry Ford HealthFollow
Zaakir Hamzavi, Henry Ford HealthFollow
Li Zhou, Henry Ford HealthFollow
Indra Adrianto, Henry Ford HealthFollow
Qing-Sheng Mi, Henry Ford HealthFollow

Recommended Citation

Vellaichamy G, Amin AT, Dimitrion P, Hamzavi Z, Zhou L, Adrianto I, and Mi QS. Recent advances in hidradenitis suppurativa: Role of race, genetics, and immunology. Front Genet 2022; 13:918858

Document Type

Article

Publication Date

1-1-2022

Publication Title

Front Genet

Abstract

Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified variants within the γ-secretase complex associated with HS; however, no definitive genotype-phenotype correlations have been made. The lack of knowledge regarding the intersection of genetics, immunology and environmental risk factors is a major obstacle to improving treatment for patients with HS. This article provides an overview of the role of race, genetics, and immunology in HS to provide insight into the multiple factors influencing the pathophysiology of HS.

PubMed ID

36092908

Volume

13

First Page

918858