The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive
Tisack A, Konda S, and Veenstra J. The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive. Arch Dermatol Res 2023.
Archives of dermatological research
Hematopoietic stem cell transplantation is increasing in frequency with graft-versus-host disease affecting many recipients. When the skin is involved, biopsy is routinely performed but often does not aid in definitive diagnosis. Here, we examine a cohort of 32 patients for potential biomarkers that can aid in the diagnosis of graft-versus-host disease. Neither blood short tandem repeat testing or neutrophil-lymphocyte ratios were predictive of rash etiology in hematopoietic stem cell transplant patients. However, skin short tandem repeat testing showed promise as a predictor in a small minority of cases in this cohort.
Medical Subject Headings
Humans; Graft vs Host Disease; Biomarkers; Biopsy; Minority Groups; Skin
ePub ahead of print