miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice
Recommended Citation
Wu D, Bi X, Qu L, Han L, Yin C, Deng J, Dong Z, Mi Q, Zhou L. miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. Experimental dermatology 2017; 26(1):82-84.
Document Type
Article
Publication Date
1-1-2017
Publication Title
Experimental dermatology
Keywords
Aminoquinolines, Animals, Down-Regulation, Imiquimod, Keratinocytes, Mice, Mice, Knockout, MicroRNAs, Psoriasis, T-Lymphocytes, Up-Regulation
Abstract
MicroRNAs (miRNAs) play very important roles in the control of immune cell and keratinocyte development and function and are implicated in skin inflammatory diseases, including psoriasis. miRNA miR-17-92 was reported to promote the differentiation of Th1 and Th1 cells and to regulate cell proliferation and apoptosis. Here we showed that imiquimod (IMQ) differentially regulates the expression of miR-17-92 cluster in the mouse skin, upregulating miR-17 and miR-19 families and downregulating miR-92. To investigate whether miR-17-92 cluster is functionally involved in the psoriasis, we have generated three mutant mice with specific deletion or overexpression of miR-17-92 cluster in keratinocytes, or with deletion of miR-17-92 cluster in T cells. Interestingly, deletion or overexpression of miR-17-92 cluster in keratinocytes, or deletion of miR-17-92 in T cells did not significantly affect IMQ-induced psoriasis-like dermatitis development in the mutant mice compared with wild-type littermates. Thus, miRNA miR-17-92 cluster may not be a key factor regulating imiqumod-induced psoriasis-like dermatitis.
Medical Subject Headings
Aminoquinolines; Animals; Down-Regulation; Imiquimod; Keratinocytes; Mice; Mice, Knockout; MicroRNAs; Psoriasis; T-Lymphocytes; Up-Regulation
PubMed ID
27579777
Volume
26
Issue
1
First Page
82
Last Page
84
