Guidelines of care for the management of acne vulgaris

Document Type

Article

Publication Date

5-1-2024

Publication Title

Journal of the American Academy of Dermatology

Abstract

BACKGROUND: Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older.

OBJECTIVE: The objective of this study was to provide evidence-based recommendations for the management of acne.

METHODS: A work group conducted a systematic review and applied the Grading of Recommendations, Assessment, Development, and Evaluation approach for assessing the certainty of evidence and formulating and grading recommendations.

RESULTS: This guideline presents 18 evidence-based recommendations and 5 good practice statements. Strong recommendations are made for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline. Oral isotretinoin is strongly recommended for acne that is severe, causing psychosocial burden or scarring, or failing standard oral or topical therapy. Conditional recommendations are made for topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, sarecycline, combined oral contraceptive pills, and spironolactone. Combining topical therapies with multiple mechanisms of action, limiting systemic antibiotic use, combining systemic antibiotics with topical therapies, and adding intralesional corticosteroid injections for larger acne lesions are recommended as good practice statements.

LIMITATIONS: Analysis is based on the best available evidence at the time of the systematic review.

CONCLUSIONS: These guidelines provide evidence-based recommendations for the management of acne vulgaris.

Medical Subject Headings

Adult; Adolescent; Humans; Acne Vulgaris; Benzoyl Peroxide; Anti-Bacterial Agents; Isotretinoin; Retinoids; Dermatologic Agents

PubMed ID

38300170

Volume

90

Issue

5

First Page

1

Last Page

1006

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