Impact of Crisaborole in Treatment-Experienced Patients With Mild-to-Moderate Atopic Dermatitis
Recommended Citation
Stein Gold LF, Tom WL, Shi V, Sanders P, Zang C, Vlahos B, and Cha A. Impact of Crisaborole in Treatment-Experienced Patients With Mild-to-Moderate Atopic Dermatitis. Dermatitis 2024; 35(1):84-91.
Document Type
Article
Publication Date
1-1-2024
Publication Title
Dermatitis : contact, atopic, occupational, drug
Abstract
Background: Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of patients with mild-to-moderate atopic dermatitis (AD).
Objective: To assess the efficacy and safety of crisaborole in patients with AD who had received prior treatment with (a) corticosteroids (systemic or topical) or topical calcineurin inhibitors (TCIs) or (b) topical corticosteroids (TCSs) or TCIs or (c) who were treatment-naive (TN).
Methods: This post hoc analysis comprised patients aged ≥2 years with mild-to-moderate AD. Patients were assigned (2:1) to receive crisaborole or vehicle twice daily for 28 days. Patient response was assessed with the Investigator's Static Global Assessment (ISGA), Dermatology Life Quality Index (DLQI), Children's Dermatology Life Quality Index (CDLQI), and Dermatitis Family Impact (DFI) tools. Safety was also assessed.
Results: A significantly higher percentage of patients treated with crisaborole versus vehicle achieved ISGA success regardless of treatment history. Patients treated with crisaborole had significant reductions in DLQI, CDLQI, and DFI scores versus those who received vehicle regardless of treatment history, with the exception of DLQI and DFI scores in the TN group. Crisaborole was well tolerated in all subgroups.
Conclusion: Crisaborole demonstrated a favorable efficacy and safety profile in both treatment-experienced and TN patients.
Medical Subject Headings
Child; Humans; Adrenal Cortex Hormones; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcineurin Inhibitors; Dermatitis, Atopic; Double-Blind Method; Ointments; Severity of Illness Index; Treatment Outcome; Child, Preschool
PubMed ID
38206678
Volume
35
Issue
1
First Page
84
Last Page
91
Comments
ClinicalTrials.gov, NCT02118766 and NCT02118792.