Standardized Protocols for Clinical and Histopathological Characterization of Hidradenitis Suppurativa Tissue Specimens
Recommended Citation
Sampath AJ, Westerkam LL, Blum FR, Alhusayen R, Bechara FG, Caffrey J, Carmona-Rivera C, Chandran NS, George R, Goldberg SR, Gudjonsson JE, Hansen SL, Ingram JR, Kirby B, Marzano AV, Matusiak Ł, Orgill DP, Prens E, van der Zee HH, van Straalen KR, Zouboulis CC, Byrd AS, Frew JW, Anne Lowes M, Naik HB, Sokumbi O, Mi QS, Miedema JR, Googe PB, and Sayed CJ. Standardized Protocols for Clinical and Histopathological Characterization of Hidradenitis Suppurativa Tissue Specimens. J Invest Dermatol 2024.
Document Type
Article
Publication Date
6-18-2024
Publication Title
The Journal of investigative dermatology
Abstract
Methods for describing and reporting the clinical and histologic characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians' and scientists' ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples. In this study, we aimed to establish a protocol for reporting histopathologic and clinical characteristics of HS tissue specimens. This study was conducted from May 2023 to August 2023. Experts in clinical care, dermatopathology, and translational research were recruited, and a modified Delphi technique was used to develop a protocol for histologic reporting and clinical characterization of submitted tissue specimens from patients with HS. A total of 27 experts participated (14 dermatologists, 3 fellowship-trained dermatopathologists, 3 plastic surgeons, 3 general surgeons, and 4 research scientists) in creating and reviewing protocols for the clinical and histopathological examination of HS tissue specimens. The protocols were formatted as a synoptic report and will help to consistently classify specimens in biobanks on the basis of histologic features and more accurately report and select samples used in translational research projects.
PubMed ID
38901775
ePublication
ePub ahead of print
