EVALUATION of 1064/650NM PICOSECOND LASER SYSTEM EFFICACY for REDUCTION of PERI-ORBITAL HYPERPIGMENTATION
Recommended Citation
Almukhtar R, Carr ES, Wu D, Goldman MP. EVALUATION of 1064/650NM PICOSECOND LASER SYSTEM EFFICACY for REDUCTION of PERI-ORBITAL HYPERPIGMENTATION. Lasers Surg Med 2022; 54(SUPPL 34):S40.
Document Type
Conference Proceeding
Publication Date
6-2-2022
Publication Title
Lasers Surg Med
Abstract
Background: Periorbital hyperpigmentation (POH) is among the most common concern of patients in an aesthetic dermatology practice. Picosecond laser (PSL) has the potential to target excessive cutaneous pigmentation while maintaining lower fluences and reduced photothermal damage. The aim of this study is to assess the effectiveness and safety of a PSL device utilizing fractionated picosecond 1064nm wavelength immediately followed by a nanosecond 650nm wavelength for management of POH. Study Design/Materials and Method: This is a single-centre, open-label clinical trial. Nine subjects 18-65 years of age of Fitzpatrick skin type I-IV with mild to moderate POH were enrolled. Subjects received a total of two treatments sessions 6 weeks apart and were followed up for 4 and 8 weeks after second treatment. Each treatment consisted of fractionated 1064nm wavelength (with pulse duration of 800 picoseconds and fluence of 0.21-0.40J/cm2) immediately followed by 650nm wavelength (pulse duration 1.6 nanoseconds, fluence of 0.38-0.48J/cm2). Investigators evaluated POH score using a 5-point scale. Measurement of melanin index was performed using a quantitative spectrometer device. Adverse events were examined by investigators and reported by subjects. Results: Fifty percent of subjects were found to have one grade improvement on POH scale at 4-week follow-up and 57% of subjects were found to have one grade improvement on POH scale at 8-week follow-up. Fifty-seven percent of subjects showed an improvement in their mean melanin scores at 4-week follow-up (percent improvement: 11.42%-14.17%) and 43% of subjects showed improvement of mean melanin scores at 8-week follow-up (percent improvement: 9.77%-38.4%). Subjects reported minimal edema and erythema lasting 1-4 days. There were no other adverse events reported. Conclusion: Two treatment sessions with fractionated picosecond 1064nm wavelength immediately followed by a nanosecond 650nm wavelength resulted in improvement of POH. Adverse events were limited to transient erythema and edema.
Volume
54
Issue
SUPPL 34
First Page
S40
