44555 A National Cancer Database Analysis of Pleomorphic Dermal Sarcoma

Document Type

Conference Proceeding

Publication Date

9-19-2023

Publication Title

J Am Acad Dermatol

Abstract

Background: Purpose: Pleomorphic dermal sarcoma (PDS) is a mesenchymal neoplasm, within the spectrum of atypical fibroxanthoma, that presents with more aggressive behavior. No recent studies have examined national incidence and mortality from PDS in the last 20 years. As such, this study examines the incidence of, associated patient characteristics, and risk factors for PDS over 1979-2019. Design: An analysis was conducted of data procured from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) registry. All cases of pleomorphic dermal sarcoma in between the years 1979-2019 were examined. A descriptive analysis was performed on patient characteristics. SEER*Stat and STATA were used to create a Kaplan-Meier survival curve and conduct a multivariable cox regression for 15-year-disease specific outcomes. Findings: The incidence of PDS between 1979 and 2019 decreased from 0.622 per 100,000 cases to 0.306 per 100,000 cases. Of the patients diagnosed with PDS in this 40-year span, 45.3% were between the ages of 60-79, 62.4% were male, and 87.5% were white. Mortality rates were lower for patients diagnosed between 2000-2018 as compared to those diagnosed between 1979-1999. Moreover, older age, non-white race, and non-head/neck site of involvement were associated with increased mortality between 1979-2019. Summary: The incidence of and mortality from PDS have decreased between 1979 and 2019. Most patients diagnosed with PDS between 1979 and 2019 were older, male, and white. Furthermore, mortality rates were highest in patients who were older, non-white, and those with malignancy of non-head/neck areas.

Volume

89

Issue

3

First Page

AB111

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