42166 Impact of Psoriasis in Special Areas on Patient Quality-of-Life Outcomes: Findings From the UPLIFT Survey in the United States

Document Type

Conference Proceeding

Publication Date

9-19-2023

Publication Title

J Am Acad Dermatol

Abstract

Background: In the global UPLIFT survey, patients with psoriasis in special areas (face, scalp, palms/soles, nails, genitals) and limited skin involvement reported high disease burden. We evaluated the impact of special area involvement on quality-of-life (QoL). Methods: UPLIFT, a multinational Web- based survey of adults with self-reported, healthcare provider–diagnosed psoriasis, was conducted March 2–June 3, 2020. We report Dermatology Life Quality Index (DLQI) results for the subset of respondents from the United States. Results: In UPLIFT, 53.2% of 1,006 US patients had psoriasis; 39.7% had psoriasis with concurrent psoriatic arthritis. Between 60.8%–86.1% of patients had a DLQI score 2:6 (at least moderately impacted QoL) across affected body surface area (BSA) subgroups (<3%, 4%–10%, >10%). In patients with psoriasis in 2:1 special area (n=701), the proportion with a DLQI score 2:21 (extremely large effect) was twice that of patients without psoriasis in special areas (n=228; 21.3% vs 10.1%, respectively). The proportions of patients with DLQI score 2:6 by special area were 75.9% (face), 73.0% (palms and/or soles), 59.5% (scalp), and 58.2% (genitals).Overall, mean scores for individual DLQI questions were greater for patients with special area involvement than those without special area involvement, particularly for pain/itch, embarrassment, and influence on clothes. Conclusions: A significant impact of psoriasis on QoL was observed regardless of extent of BSA affected. Involvement of special areas, especially face and palms and/or soles, had a large effect on DLQI. Special area involvement is an important clinical consideration for QoL, even in patients with limited skin involvement.

Volume

89

Issue

3

First Page

AB176

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