42166 Impact of Psoriasis in Special Areas on Patient Quality-of-Life Outcomes: Findings From the UPLIFT Survey in the United States
Recommended Citation
Merola JF, Ogdie A, Gottlieb AB, Stein Gold LF, Flower A, Jardon S, Deignan C, Lebwohl MG. 42166 Impact of Psoriasis in Special Areas on Patient Quality-of-Life Outcomes: Findings From the UPLIFT Survey in the United States. J Am Acad Dermatol 2023; 89(3):AB176.
Document Type
Conference Proceeding
Publication Date
9-19-2023
Publication Title
J Am Acad Dermatol
Keywords
adult, body surface, clothing, conference abstract, controlled study, Dermatology Life Quality Index, embarrassment, female, genital system, health care personnel, human, major clinical study, male, outcome assessment, pain, psoriasis, psoriatic arthritis, quality of life, scalp, United States
Abstract
Background: In the global UPLIFT survey, patients with psoriasis in special areas (face, scalp, palms/soles, nails, genitals) and limited skin involvement reported high disease burden. We evaluated the impact of special area involvement on quality-of-life (QoL). Methods: UPLIFT, a multinational Web- based survey of adults with self-reported, healthcare provider–diagnosed psoriasis, was conducted March 2–June 3, 2020. We report Dermatology Life Quality Index (DLQI) results for the subset of respondents from the United States. Results: In UPLIFT, 53.2% of 1,006 US patients had psoriasis; 39.7% had psoriasis with concurrent psoriatic arthritis. Between 60.8%–86.1% of patients had a DLQI score 2:6 (at least moderately impacted QoL) across affected body surface area (BSA) subgroups (<3%, 4%–10%, >10%). In patients with psoriasis in 2:1 special area (n=701), the proportion with a DLQI score 2:21 (extremely large effect) was twice that of patients without psoriasis in special areas (n=228; 21.3% vs 10.1%, respectively). The proportions of patients with DLQI score 2:6 by special area were 75.9% (face), 73.0% (palms and/or soles), 59.5% (scalp), and 58.2% (genitals).Overall, mean scores for individual DLQI questions were greater for patients with special area involvement than those without special area involvement, particularly for pain/itch, embarrassment, and influence on clothes. Conclusions: A significant impact of psoriasis on QoL was observed regardless of extent of BSA affected. Involvement of special areas, especially face and palms and/or soles, had a large effect on DLQI. Special area involvement is an important clinical consideration for QoL, even in patients with limited skin involvement.
Volume
89
Issue
3
First Page
AB176
