"54585 Vitiligo, Nutrition and the Gut Microbiome: A Narrative Review" by Marlee Hewitt, Karan Pandher et al.
 

54585 Vitiligo, Nutrition and the Gut Microbiome: A Narrative Review

Document Type

Conference Proceeding

Publication Date

9-1-2024

Publication Title

J Am Acad Dermatol

Abstract

Introduction: Affecting up to two percent of individuals worldwide, vitiligo is an acquired chronic depigmenting skin disease. The pathogenesis is thought to be multifactorial. Theories involving the role of the gastrointestinal microbiome in the pathogenesis of vitiligo have been suggested. As such, a comprehensive literature review was conducted to determine the possible role of the gut microbiome in the pathogenesis of vitiligo. Methods: MEDLINE databases were searched in May 2023 using keywords such as vitiligo and gut microbiome. Results: Four articles between 2020 and 2023 were reviewed (1 murine model study, 3 case control studies). The murine study determined Bacteriodes species had a protective role against skin depigmentation. 72 vitiligo patients were studied across the case-control studies. All three studies found that individuals with vitiligo had gut dysbiosis compared to their healthy controls. Additionally, these studies found that the gut microbiome of individuals with vitiligo had a significant decrease in the Bacteriodes species and an increase in Pseudomonas, Psychrobacter, and Butyricioccis. Discussion: Overall, the evidence reported suggests that the gut microbiome is altered in individuals with vitiligo. The protective effect of Bacteriodes species in the murine model and decrease of this species in individuals with vitiligo indicate the gut microbiome may play a role in vitiligo pathogenesis. Additionally, the increase in certain bacteria species indicates these bacteria may impact the progression of depigmentation. As a result, further investigation into the role of the gut microbiome in vitiligo is needed and could present an interesting target for treatment in the future.

Volume

91

Issue

3

First Page

AB98-AB98

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