"54853 Trends in Incidence and Mortality of Pleomorphic Dermal Sarcoma:" by Mustufa Jafry and Molly Powers
 

54853 Trends in Incidence and Mortality of Pleomorphic Dermal Sarcoma: A Retrospective Cohort Study Using SEER Data

Document Type

Conference Proceeding

Publication Date

9-1-2024

Publication Title

J Am Acad Dermatol

Abstract

Objective: This retrospective cohort study aimed to investigate changes in PDS incidence over 40 years and identify risk factors associated with PDS mortality. The study hypothesized an increase in incidence over time due to various factors, as well as differences in mortality based on age, sex, ethnicity, stage at diagnosis, tumor size, treatment modalities, and comorbidities. Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) Program, covering patients diagnosed with PDS from 1979 to 2019, were utilized for this study. Incidence and mortality rates were calculated using SEER*Stat software, and joinpoint models analyzed trends in incidence and mortality rates. Factors associated with PDS incidence and mortality were identified using chi-square tests and t-tests, respectively. Multivariable Cox regression analysis was performed to determine significant predictors of mortality. Results: Data from 567 PDS patients were analyzed. The incidence of PDS increased steadily over four decades, with a net incidence of 0.508 per 100,000 cases in 2018-2019. PDS incidence was higher among older males, white individuals, and those with head and neck involvement. The overall survival rate improved significantly over time. Factors associated with increased mortality risk included older age, non-white race, and non-head/neck site of involvement. Discussion: This study highlights a decreasing trend in PDS incidence and mortality over the past 20 years, possibly due to advancements in diagnosis and treatment. However, certain patient groups, such as older individuals and non-white patients with malignancy in non-head/neck areas, have higher mortality rates, warranting further investigation and targeted interventions.

Volume

91

Issue

3

First Page

AB347

Find It @ Sladen

Share

COinS