287 Effects of ruxolitinib cream on pruritus in black patients with atopic dermatitis
Recommended Citation
Eichenfield LF, Stein Gold LF, Brar KK, Chiesa Fuxench ZC, Silverberg JI, Venturanza ME, Kallender H, Gao J, Szepietowski JC. 287 Effects of ruxolitinib cream on pruritus in black patients with atopic dermatitis. J Invest Dermatol 2022; 142(8):S49.
Document Type
Conference Proceeding
Publication Date
8-1-2022
Publication Title
J Invest Dermatol
Keywords
endogenous compound, Janus kinase, Janus kinase 2 inhibitor, ruxolitinib, adult, atopic dermatitis, body surface, conference abstract, controlled study, drug therapy, eczema, female, human, male, meta analysis, monotherapy, numeric rating scale, phase 3 clinical trial (topic), pruritus, randomized controlled trial (topic)
Abstract
Atopic dermatitis (AD) is an inflammatory skin disease that has phenotypic differences across race and can be more severe in Black patients. In two phase 3 identical design studies (TRuE-AD1/TRuE-AD2), patients (≥12 years old with AD for ≥2 years, Investigator’s Global Assessment [IGA] score 2/3, 3%–20% affected body surface area) were randomized (2:2:1) to twice-daily 0.75% or 1.5% ruxolitinib (Janus kinase [JAK]1/JAK 2 inhibitor) cream or vehicle for 8 weeks. Here we describe the effect of ruxolitinib cream on itch in Black patients using pooled data from the 2 studies (n=292). Mean itch numerical rating scale (NRS) score at baseline was 5.3/5.4 for ruxolitinib cream (0.75%/1.5%) and 5.7 for vehicle. Reductions in mean itch NRS score with ruxolitinib cream (0.75%/1.5%) were evident within approximately 12 hours of first application (–0.6/–0.7 vs −0.2 for vehicle), with statistically significant reductions by Day 4 vs vehicle (–1.4/–1.6 vs –0.6; both P<0.05). For those with baseline itch NRS ≥4 (n=187; 64.0%), more patients achieved ≥4-point itch NRS improvement vs vehicle by Day 2 (6.1%/16.4% vs 0%); this increased to 15.9%/26.6% vs 3.0% on Day 7 and 30.1%/43.2% vs 17.5% at Week 8 (P=0.212/P=0.009). More patients applying 0.75%/1.5% ruxolitinib cream vs vehicle reported no days of itch per question 1 of the Patient-Oriented Eczema Measure (POEM) at Week 2 (19.0%/19.4% vs 5.3%); this increased at Week 8 (34.0%/30.8% vs 12.2%). In summary, ruxolitinib cream monotherapy over 8 weeks was associated with rapid and considerable itch relief in Black patients with AD.
Volume
142
Issue
8
First Page
S49
