Comorbidities Associated with Cutaneous Lichen Planus: A Systematic Review

Document Type

Conference Proceeding

Publication Date

11-10-2025

Publication Title

J Invest Dermatol

Keywords

Dermatology

Abstract

Lichen planus is a chronic inflammatory disorder of the skin and mucous membranes. While oral lichen planus has been the focus of multiple systematic reviews on comorbid conditions such as thyroid disease, hepatitis C, and autoimmune disorders, the comorbidity profile of cutaneous lichen planus (CLP) has not been systematically evaluated. Understanding these associations is important for comprehensive patient care and for guiding screening strategies. The objective of this review is to systematically identify, appraise, and synthesize the evidence on comorbidities associated with cutaneous lichen planus in adult patients. A systematic search will be conducted in Embase, Web of Science, Scopus, and Cochrane Library from inception to August 2025. Eligible studies will include observational studies (cross-sectional, case-control, cohort) and clinical registries that report comorbidities in patients with cutaneous lichen planus. Studies exclusively on oral or genital lichen planus will be excluded. Narrative synthesis will be performed, and where data allow, meta-analysis will be conducted for specific comorbidities, such as metabolic syndrome, cardiovascular disease, thyroid disorders, autoimmune conditions, psychiatric disorders, malignancy, and viral infections. We anticipate identifying a broad range of comorbidities reported in CLP, with particular overlap in metabolic, autoimmune, and psychiatric conditions. The review will clarify whether these associations are robust and distinct from those seen in oral lichen planus. This will be the first systematic review to comprehensively evaluate comorbidities associated specifically with cutaneous lichen planus. The findings will have clinical relevance for dermatologists and primary care providers in improving screening, early detection, and holistic management of CLP patients.

Volume

145

Issue

11

First Page

1

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