Clinical Demonstration of Pigmentation Response in Individuals with Fitzpatrick Skin Type V Following Irradiation with Novel Light Source at the Ultraviolet(Uv) / Visible Boundary Region

Document Type

Conference Proceeding

Publication Date

7-1-2026

Publication Title

J Am Acad Dermatol

Keywords

Dermatology

Abstract

Sunlight is comprised of ∼45% Visible Light (VL) and 4-5% Ultraviolet(UV)A (320-400 nm), both shown clinically to induce erythema and pigmentation. Current UV filters provide protection against UVB and portions of UVA, but the protection level tapers off in the Longest UVA (LUVA), beyond 380 nm into the visible wavelengths. To evaluate the skin impact of boundary region light exposure, a single-center, controlled clinical study was conducted using a novel, modified multiport 601S, xenon arc solar simulator customized to produce a narrow output radiation spectrum of either LUVA (380-400 nm) alone or Boundary Region light LUVA+HEVL (380-420 nm). Subsites were administered with LUVA doses 2.7, 4.7, 8.2, 14.3, 25, 43.8 J/cm2 and LUVA+HEVL doses 5.3, 9.3, 16.3, 28.6, 50, 87.5 J/cm2. Pigmentation was studied in 8 female subjects, 18 to 40 years old with Fitzpatrick Skin Type V. Visual global assessment scale (0-2) was used to identify pigmentation responses. Both regimens induced clinically perceptible pigmentation at 15 minutes post-exposure indicating immediate pigment darkening (IPD) and at 24, 48, 72 hour time points post-exposure indicating persistent pigment darkening (PPD). IPD was induced at an average dose of 6.09 J/cm2(380-400 nm) and 17.18 J/cm2(380-420 nm) equating to 1.5 hours of natural sunlight exposure. 50% of the subjects exposed to LUVA and 62.5% to Boundary Region Light exhibited persistent pigmentation at 72 hours. This study validates the use of the novel boundary region light source in the evaluation of skin pigmentation response to enable future skin protection studies.

Volume

95

Issue

1

First Page

AB105

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