Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study

Authors

David W. Dempster
Hua Zhou
Robert R. Recker
Jacques P. Brown
Christopher P. Recknor
E M. Lewiecki
Paul D. Miller
Sudhaker D. Rao, Henry Ford HealthFollow
David L. Kendler
Robert Lindsay
John H. Krege
Jahangir Alam
Kathleen A. Taylor
Boris Janos
Valerie A. Ruff

Recommended Citation

Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Janos B, and Ruff VA. Differential effects of teriparatide and denosumab on intact PTH and bone formation indices: AVA osteoporosis study. J Clin Endocrinol Metab 2016; 101(4):1353-63.

Document Type

Article

Publication Date

4-1-2016

Publication Title

The Journal of clinical endocrinology and metabolism

Abstract

We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab.

Medical Subject Headings

Aged; Aged, 80 and over; Anabolic Agents; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Middle Aged; Osteogenesis; Osteoporosis, Postmenopausal; Parathyroid Hormone; Teriparatide

PubMed ID

26859106

Volume

101

Issue

4

First Page

1353

Last Page

1363