Effect of curative parathyroidectomy on insulin resistance
Recommended Citation
Putnam R, Dhibar DP, Varshney S, Behera A, Mittal BR, Bhansali A, Rao SD, and Bhadada SK. Effect of curative parathyroidectomy on insulin resistance. Indian J Endocrinol Metab 2016; 20(6):784-789.
Document Type
Article
Publication Date
11-1-2016
Publication Title
Indian J Endocrinol Metab
Abstract
BACKGROUND: Primary hyperparathyroidism (PHPT) is characterized by inappropriately elevated serum parathyroid hormone (PTH) level despite elevated serum calcium. Insulin resistant is the basic pathophysiology, behind the higher prevalence of diabetes mellitus in patients with PHPT. However, the improvement in insulin resistance (IR) after curative parathyroidectomy (CPTX) has not been established yet, as the study results are conflicting.
MATERIALS AND METHODS: In this prospective interventional study, ten patients with mild PHPT (Group 1) and another ten patients with moderate to severe PHPT (Group 2) were undergone CPTX. The IR was assessed by homeostasis model assessment-IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), and fasting serum insulin (FSI), before and 3 months after CPTX.
RESULTS: There was no significant change of FPG and FSI, before and after CPTX in Group 1 (
CONCLUSION: IR remained unchanged after CPTX in mild as well as moderate to severe PHPT. Asymptomatic PHPT with abnormal IR should not be used as criteria for parathyroidectomy.
PubMed ID
27867880
Volume
20
Issue
6
First Page
784
Last Page
789
