Docetaxel-Induced Systemic Sclerosis with Internal Organ Involvement Masquerading as Congestive Heart Failure
Recommended Citation
Park B, Vemulapalli RC, Gupta A, Shreve ME, and Rees DA. Docetaxel-induced systemic sclerosis with internal organ involvement masquerading as congestive heart failure. Case Reports Immunol 2017; 2017:4249157.
Document Type
Article
Publication Date
1-1-2017
Publication Title
Case Reports Immunol
Abstract
Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys. Docetaxel is a chemotherapeutic agent which has been associated with cutaneous side effects. An uncommon cutaneous side effect of docetaxel is scleroderma-like skin changes that extend from limited to diffuse cutaneous systemic sclerosis. Several case reports have been published regarding the association of docetaxel and systemic sclerosis. However, those reports demonstrated the association between docetaxel and scleroderma-like skin changes without internal organ involvement. Here, we report a case of systemic sclerosis with pulmonary arterial hypertension and a microangiopathic kidney involvement induced by docetaxel chemotherapy. After an exhaustive literature review, this could be the first case of docetaxel-induced systemic sclerosis involving internal organs.
PubMed ID
28265474
Volume
2017
First Page
4249157
Last Page
4249157
