Epidemiology and Management of Infections in Liver Transplant Recipients
Recommended Citation
Amjad W, Hamaad Rahman S, Schiano TD, and Jafri SM. Epidemiology and Management of Infections in Liver Transplant Recipients. Surg Infect (Larchmt) 2024; 25(4):272-290.
Document Type
Article
Publication Date
5-1-2024
Publication Title
Surgical infections
Abstract
Background: Improvements in liver transplant (LT) outcomes are attributed to advances in surgical techniques, use of potent immunosuppressants, and rigorous pre-LT testing. Despite these improvements, post-LT infections remain the most common complication in this population. Bacteria constitute the most common infectious agents, while fungal and viral infections are also frequently encountered. Multi-drug-resistant bacterial infections develop because of polymicrobial overuse and prolonged hospital stays. Immediate post-LT infections are commonly caused by viruses.
Conclusions: Appropriate vaccination, screening of both donor and recipients before LT and antiviral prophylaxis in high-risk individuals are recommended. Antimicrobial drug resistance is common in high-risk LT and associated with poor outcomes; epidemiology and management of these cases is discussed. Additionally, we also discuss the effect of coronavirus disease 2019 (COVID-19) infection and monkeypox in the LT population.
Medical Subject Headings
Humans; Bacterial Infections; COVID-19; Liver Transplantation; Mycoses; Postoperative Complications; SARS-CoV-2; Transplant Recipients; Virus Diseases
PubMed ID
38700753
Volume
25
Issue
4
First Page
272
Last Page
290
