Acute onset nitrofurantoin-induced autoimmune hepatitis after urinary tract infection treatment
Recommended Citation
Chaudhary AJ, Khan MZ, Sohail A, Zaidi SMH, Denha E, and Venkat D. Acute onset nitrofurantoin-induced autoimmune hepatitis after urinary tract infection treatment. Clin Case Rep 2024; 12(6):e9050.
Document Type
Article
Publication Date
6-1-2024
Publication Title
Clin Case Rep
Abstract
KEY CLINICAL MESSAGE: This case signifies the importance of recognizing DIAIH within the context of antibiotic therapy, especially in older adults and even shortly after common drug exposures for treating UTI.
ABSTRACT: Various drugs can induce immune-mediated liver damage and in rare instances may lead to autoimmune hepatitis. Here we report an 84-year-old woman who developed autoimmune hepatitis less than 3 weeks after treatment for urinary tract infection with the antibiotic nitrofurantoin. She presented with jaundice, right upper quadrant abdominal pain, nausea, and vomiting. In the absence of a history of an autoimmune disorder or elevated liver enzymes in the past; elevated liver enzymes after a short course of Nitrofurantoin and the presence of smooth muscle antibodies strongly suggested autoimmune hepatitis, which was confirmed through biopsy sample analysis. The patient scored 7 points on the Naranjo adverse reaction probability scale. The patient's rapid recovery within 1 month of prednisone therapy supports the association of liver damage with nitrofurantoin use.
PubMed ID
38868111
Volume
12
Issue
6
First Page
9050
Last Page
9050
