The Straw That Broke the Camel's Back: Amoxicillin-Clavulanate Unraveling Autoimmune Hepatitis in a Previously Asymptomatic Female

Authors

John A. Gallagher, Henry Ford HealthFollow
Yara Dababneh, Henry Ford HealthFollow
Andrew Gregory, Henry Ford HealthFollow
Beena U. Ahsan, Henry Ford HealthFollow
Humberto C. Gonzalez, Henry Ford HealthFollow

Recommended Citation

Gallagher JA, Dababneh Y, Gregory A, Ahsan BU, and Gonzalez HC. The Straw That Broke the Camel's Back: Amoxicillin-Clavulanate Unraveling Autoimmune Hepatitis in a Previously Asymptomatic Female. Cureus 2025;17(8):e91240.

Document Type

Article

Publication Date

8-1-2025

Publication Title

Cureus

Keywords

acute liver failure; amoxicillin-clavulanate; autoimmune hepatitis; drug-induced liver injury; histopathology; immunosuppressive therapy

Abstract

Drug-induced liver injury (DILI) is a challenging diagnosis. Treatment generally involves cessation of the offending agent. In rare cases, DILI may present with autoimmune features that may necessitate immunosuppressive treatment, as in drug-induced autoimmune hepatitis (DIAIH). Distinguishing DIAIH from classic idiopathic autoimmune hepatitis (cAIH) may be difficult, as cAIH can also present after DILI and typically requires long-term immunosuppression for treatment. We describe a case of a 61-year-old female who presented with jaundice and abnormal liver function tests several months after taking amoxicillin-clavulanate. A comprehensive workup with long-term monitoring later revealed the cause of her condition, an unusual diagnosis in a previously healthy individual.

PubMed ID

41030704

Volume

17

Issue

8

First Page

91240

Last Page

91240