Recommended Citation
Dig Dis Sci 2017; 62(11):3221-3234.
Document Type
Article
Publication Date
11-1-2017
Publication Title
Digestive diseases and sciences
Keywords
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Alcohol Drinking, Aspartate Aminotransferases, Biomarkers, Blood Platelets, Carcinoma, Hepatocellular, Clinical Enzyme Tests, Decision Support Techniques, Hepatitis C, Chronic, Humans, Kaplan-Meier Estimate, Liver Neoplasms, Middle Aged, Platelet Count, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Reproducibility of Results, Risk Assessment, Risk Factors, Time Factors, United States, Young Adult
Abstract
BACKGROUND: Risk of hepatocellular carcinoma (HCC) may be difficult to determine in the clinical setting.
AIM: Develop a scoring system to forecast HCC risk among patients with chronic hepatitis C.
METHODS: Using data from the Chronic Hepatitis Cohort Study collected during 2005-2014, we derived HCC risk scores for males and females using an extended Cox model with aspartate aminotransferase-to-platelet ratio index (APRI) as a time-dependent variables and mean Kaplan-Meier survival functions from patient data at two study sites, and used data collected at two separate sites for external validation. For model calibration, we used the Greenwood-Nam-D'Agostino goodness-of-fit statistic to examine differences between predicted and observed risk.
RESULTS: Of 12,469 patients (1628 with a history of sustained viral response [SVR]), 504 developed HCC; median follow-up was 6 years. Final predictors in the model included age, alcohol abuse, interferon-based treatment response, and APRI. Point values, ranging from -3 to 14 (males) and -3 to 12 (females), were established using hazard ratios of the predictors aligned with 1-, 3-, and 5-year Kaplan-Meier survival probabilities of HCC. Discriminatory capacity was high (c-index 0.82 males and 0.84 females) and external calibration demonstrated no differences between predicted and observed HCC risk for 1-, 3-, and 5-year forecasts among males (all p values >0.97) and for 3- and 5-year risk among females (all p values >0.87).
CONCLUSION: This scoring system, based on age, alcohol abuse history, treatment response, and APRI, can be used to forecast up to a 5-year risk of HCC among hepatitis C patients before and after SVR.
Medical Subject Headings
Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alcohol Drinking; Aspartate Aminotransferases; Biomarkers; Blood Platelets; Carcinoma, Hepatocellular; Clinical Enzyme Tests; Decision Support Techniques; Hepatitis C, Chronic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Middle Aged; Platelet Count; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Reproducibility of Results; Risk Assessment; Risk Factors; Time Factors; United States; Young Adult
PubMed ID
28965221
Volume
62
Issue
11
First Page
3221
Last Page
3234
