The Effects of Demographic Factors Upon Intestinal Transplant Outcomes

Document Type

Conference Proceeding

Publication Date

8-1-2025

Publication Title

Am J Transplant

Abstract

Purpose: Demographic factors are increasingly recognized as potential influences on transplant outcomes. Limited data exist on the impact of demographic factors on intestinal transplantation (IT) and multivisceral transplantation (MVT) outcomes. This study aims to evaluate the impact of both sex and age on IT and MVT post-transplant outcomes. Methods: Retrospective chart review of all patients who underwent IT or MVT at an academic transplant center from 2010 to 2023. Patients were stratified by sex (male vs. female) and age (<50 vs. ≥50 years). The primary outcome was patient survival, analyzed using Kaplan-Meier analysis. Secondary outcomes included graft failure (GF), reoperation rates, moderate-to-severe rejection, and the development of chronic kidney disease (CKD). Results: Among 50 IT recipients, there were 20 men and 30 women. When stratified by age, 21 were <50 years old, while 29 were ≥50 years old. IT alone accounted for 58% of transplants, while 42% were MVT. Survival analysis revealed no significant mortality difference between the groups when analyzed by sex (p=0.28) or when comparing IT alone to MVT (p=>0.05 in all subgroups). Male IT recipients showed a higher need for reoperation within 1 month (p=0.01), though this difference did not persist at 3 months (p=0.44). No significant differences were observed between the sexes for GF, rejection rates, or CKD. In contrast, age was a significant predictor of survival, with recipients ≥50 years old demonstrating significantly lower survival rates than younger recipients (p<0.01). Older recipients had a trend towards higher incidence of reoperation within 3 months and an increased risk of developing CKD. No significant differences were found between age groups in terms of GF or rejection rate. Conclusions: While transplant recipient sex did not significantly impact survival or transplant-related outcomes, age ≥50 years was associated with significantly lower survival rates following IT. Further studies are needed to explore immunosuppression modifications and infectious surveillance strategies that may help reduce the incidence of CKD and improve mortality outcomes in these populations. CITATION INFORMATION: Toiv A., O'Brien H., Andrews T., Jafri S. The Effects of Demographic Factors Upon Intestinal Transplant Outcomes AJT, Volume 25, Issue 8 Supplement 1 DISCLOSURES: A. Toiv: None.

Volume

25

Issue

8

First Page

S840

Last Page

S841

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