Recommended Citation
Godbole M, Wani K, Zia S, and Dabak V. Carcinoma En Cuirasse: A Rare but Striking Cutaneous Manifestation of Metastatic Breast Cancer. Cureus 2023; 15(6):e39838.
Document Type
Article
Publication Date
6-1-2023
Publication Title
Cureus
Abstract
Carcinoma en cuirasse is a rare cutaneous metastatic presentation of breast cancer with a poor prognosis. We report a female in her 70s with a prior history of left breast ductal carcinoma in situ status post-radiation and lumpectomy who presented with skin thickening of the left breast and a few solid masses in bilateral breasts. Biopsy showed invasive ductal carcinoma of the left breast (estrogen receptor [ER]/progesterone receptor positive [PR], human epidermal growth factor receptor-2 [HER2] negative) and ductal carcinoma in situ of the right breast (ER/PR positive). She underwent a right breast lumpectomy; however, the left breast mastectomy was aborted due to the worsening of her skin findings on preoperative examination. A skin biopsy revealed poorly differentiated invasive ductal carcinoma. She was diagnosed with stage 4 breast cancer, specifically carcinoma en cuirasse. Systemic treatment was initiated, followed by a left breast mastectomy. A surgical biopsy was HER2-positive, and therefore anti-HER2 therapy was given. She remains on maintenance therapy with an excellent response at present.Any unexplained skin findings in breast cancer patients should prompt consideration of carcinoma en cuirasse. With ongoing treatment advances, many newer therapy options are available for metastatic breast cancer. Based on our case, we think that patients with this disease can have better outcomes.
Medical Subject Headings
Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Drug Interactions; Drug Synergism; Electroencephalography; Ethanol; Flurazepam; Humans; Hypnotics and Sedatives; Male; Placebos; Sleep; Time Factors
PubMed ID
37397657
Volume
15
Issue
6
First Page
39838
Last Page
39838
