Images in Immunotherapy and Precision Oncology: A Case Report of Neurofibromatosis-1

Document Type

Article

Publication Date

5-1-2024

Publication Title

J Immunother Precis Oncol

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that primarily causes the growth of tumors along nerves. Additionally, the germline mutations involved in NF1 predispose patients to develop further malignancies. The mainstay initial treatment for these malignancies is surgical removal at diagnosis, although targeted therapies are under evaluation in the relapsed setting. We report a case of malignant peripheral nerve sheath tumor (MPNST), gastrointestinal stromal tumor (GIST), and pheochromocytoma in a patient with NF1 who presented with an infected right shoulder lesion that was confirmed to be spindle cell sarcoma via biopsy. She was treated with antibiotics; however, she rapidly deteriorated and opted for hospice care.

PubMed ID

38721407

Volume

7

Issue

2

First Page

122

Last Page

125

Find It @ Sladen

Share

COinS