Pancreatic Cancer-Associated Fibroblasts: Where do we go from here?
Recommended Citation
Carpenter ES, Vendramini-Costa DB, Hasselluhn MC, Maitra A, Olive KP, Cukierman E, Pasca di Magliano M, and Sherman MH. Pancreatic Cancer-Associated Fibroblasts: Where do we go from here? Cancer Res 2024.
Document Type
Article
Publication Date
9-16-2024
Publication Title
Cancer research
Abstract
Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which cancer-associated fibroblasts (CAFs) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address.
PubMed ID
39283867
ePublication
ePub ahead of print
