A perilous and complicated situation in hospitals: Vitamin D deficiency in multiple myeloma patients-A nationwide cross-sectional study
Recommended Citation
Lakhanpal MR, Chelikam N, Manjani D, Lahori S, Akella SA, Shivashankar PG, Shah SV, Ali A, Toor V, Singh A, Gujarathi R, Manjani L, Patel U, Adiga A, Kukreja G. A perilous and complicated situation in hospitals: Vitamin D deficiency in multiple myeloma patients-A nationwide cross-sectional study. J Clin Oncol 2023; 41(16):e20010.
Document Type
Conference Proceeding
Publication Date
6-1-2023
Publication Title
J Clin Oncol
Abstract
Background: For the year 2019, the United States age-adjusted rate of new Multiple Myeloma (MM) cases was 6.8 per 100,000 people and the age-adjusted death rate was 3 per 100,000 people. Vitamin D Deficiency (VDD) and associated complications are very common in MM patients. Aim of our study was to evaluate the prevalence and risk of VDD in patients with MM and VDD associated disability and mortality in the VDD patients. Methods: We performed a cross-sectional retrospective analysis of Nationwide Inpatient Sample data 2016-2018. Adults hospitalizations with MM were identified using ICD 10 code. Hospitalized patients were grouped into patients with VDD and without VDD. We ran chi square, unpaired-t test and mixed-effect survey logistic regression analysis to find out odds ratio and 95%CI showing outcomes of VDD in MM patients. Results: We found 330,175 hospitalizations with MM. Of these 11,480 were noted to be patients with VDD with higher prevalence (0.64% vs 0.37%) of and strong association (aOR:1.41, 95%CI:1.35-1.47) with MM in comparison without MM. Amongst MM, females [1.50, 1.49-1.51], black race [1.23, 1.22-1.24], urban teaching hospitals [1.22, 1.22- 1.23], and hospitals in mid-west region [1.30, 1.29- 1.32] had higher prevalence odds of VDD compared with males, white race population, rural hospitals and hospitals in northeast region. (p<0.0001) Patients with VDD had higher prevalence and strong association with higher morbidity [5.1% vs 3.9%, 1.24,1.14-1.36; c-value=0.67], severe/extreme disability [77.2% vs 73.3%, 1.26, 1.20-1.33; c-value=0.73], and discharge to locations other than home [51.15% vs 45.69%, 1.29, 1.23-1.34; c-value=0.69] in comparison without VDD. (p<0.0001) [Table]. Conclusions: Significant poor outcomes warrant early identification of VDD and role of same hospitalization vitamin D replacement amongst MM patients with higher risk.
Medical Subject Headings
Hematology
PubMed ID
Not assigned.
Volume
41
Issue
16
First Page
e20010
