This report of the beneficial response in central nervous system (CNS) manifestations of a patient with Hodgkin's disease to the intrathecal administration of cytosine arabinoside suggests that this drug may have value in the treatment of CNS involvement by lymphoma and acute leukemia and of some brain tumors. Its use, for the first time via the intrathecal route in the present case, was well tolerated in two series of treatments.
Van Slyck, Ellis J. and Talley, Robert W.
"Intrathecal Cytosine Arabinoside in Hodgkin's Disease With Central Nervous System Manifestations,"
Henry Ford Hospital Medical Journal
: Vol. 15
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol15/iss4/3