A theoretical approach to the unknown etiology of multiple sclerosis is presented in this preliminary study which reports the results of empiric treatment with azathioprine. Imuran® therapy produced stabilization of the disease, neurological improvement, and no progress of neurological dysfunction or loss of any regained function. Evidence points toward a viral-induced immunological defect. Abnormal gamma globulins found in the cerebral spinal fluid suggest an immunological etiology.
Tucker, William G. and Kapphahn, K. H.
"A Preliminary Evaluation of Azathioprine (Imuran®) in the Treatment of Multiple Sclerosis,"
Henry Ford Hospital Medical Journal
: Vol. 17
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol17/iss2/3