Henry Ford Hospital Medical Journal


A Negro woman with alcaptonuria, ochronosis, ochronotic arthropathy, diabetes mellitus and mycosis fungoides died of acute renal failure due to diabetic glomerulonephropathy and ochronotic nephrosis. The role of the renal lesions of ochronosis is presented in potentiating the effect of an underlying renal disease producing rapidly progressive kidney failure. The occurrence of ochronosis, diabetes mellitus and mycosis fungoides is apparently coincidental only. Special stains of tissue sections confirm the similarity of melanin and ochronotlc pigment.