A study was done to evaluate the dose-response of cholecystokinin administered intravenously to normal patients and to patients with diseased gallbladders. The volumes of bile and bilirubin units were measured in duodenal aspirates. A dosage of cholecystokinin between 12.5 and 25 Ivy dog units differentiated the several categories studied. Lower doses of cholecystokinin resulted in no change in the volume of bile, but significantly reduced the output of bilirubin units.
Priest, Robert J.; Gluckmann, Roberto F.; Berk, J. Edward; and Rinaldo, Joseph A.
"Dose-Response Relationship of Bile Flow to Cholecystokinin Stimulation as Measured by Duodenal Drainage,"
Henry Ford Hospital Medical Journal
: Vol. 18
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol18/iss4/7