Research findings in the last 20 years concerning senile and postmenopausal osteoporosis indicate that the skeletal condition associated with these diseases arises because some systemic factor acts directly upon the bone marrow tissues. There is a secondary tendency to accelerate loss of bone greater than in the normal aging process. The loss occurs only on those surfaces in physical contact with the bone marrow tissue.
Frost, Harold M.
"Postmenopausal Osteoporosis: The evolution of our concepts of its cause,"
Henry Ford Hospital Medical Journal
: Vol. 20
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol20/iss2/6