In a retrospective study, hepatitis B antigen (HB Ag) was found in 14 lots of human plasma pools (16-20 liters each) that had been treated by the combined Betaprone (BPL) with ultraviolet (UV) irradiation procedure. No evidence of clinical hepatitis was found during a six-month follow-up after 185.2 liters of HB Ag positive plasma were Infused into 257 patients. Since HB Ag positive blood products treated by BPL with UV produced no clinical hepatitis, it is evident that our treatment is efficacious against hepatitis virus agents.
LoGrippo, Gerald A. and Hayashi, Hajime
"Efficacy of Betaprone with Ultraviolet Irradiation on Hepatitis B Antigen in Human Plasma Pools (A Retrospective Study),"
Henry Ford Hospital Medical Journal
: Vol. 21
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol21/iss4/4