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Henry Ford Hospital Medical Journal

Abstract

Glucagon alone or in combination with methylprednisolone was an adequate therapeutic adjuvant for pancreatectomized recipients of whole pancreas allografts. All recipients were minimally immunosuppressed with azathioprine, 5.0 mg/K/day for three days, then 2.5 mg/K/day. The morphological, functional, and survival response after whole pancreas transplantation indicated a trend of improvement in the treated groups. Only the groups of dogs receiving glucagon alone or in combination with methylprednisolone survived more than two weeks after transplantation. This therapy has proven to be effective for whole pancreas transplantation.

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