The effect of different dosage levels (0-100 mg/k/day x 3)of intravenous methylprednisolone was tested in canine kidney autografts undergoing immediate contralateral nephrectomy. Intravenous methylprednisolone was safely administered in doses up to 40 mg/k/day for three days after kidney transplantation. Higher doses ( 40 mg/k/day x 3) were functionally and structurally harmful to canine kidney autografts.
Valjee, Krishna D. and Toledo-Pereyra, Luis H.
"Intravenous Methylprednisolone for Kidney Transplantation,"
Henry Ford Hospital Medical Journal
: Vol. 26
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol26/iss3/9