Henry Ford Hospital Medical Journal


A mother with mixed connective tissue disease (MCTD) and a daughter with systemic lupus erythematosus (SLE) were simultaneously diagnosed and treated in August, 1977. Multiple cases of SLE occurring in the same family are not rare, but the frequency with which systemic lupus erythematosus and mixed connective tissue disease occurs in the same family is not known, and the reports are few. This report describes these two cases and suggests that mixed connective tissue disease may be part of the spectrum of systemic lupus erythematosus.



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