Henry Ford Hospital Medical Journal


In vivo studies of bile salt absorption and distribution using 14C-taurocholate were made in fed and fasted, intact and cholecystectomized Syrian hamsters. There was no significant difference in the rate of ileal 14C-bile salt absorption or the distribution of 14C-bile salts among the compartments of the enterohepatic circulatory system in any of the animals. The results showed that the sphincter of Oddi is patent in fasting, intact and cholecystectomized hamsters. They also suggested that the diminished bile salt pool seen in fasted, cholecystectomized but not in intact hamsters arises from a) a primary, fasting-induced decrease in liver enzyme activity involved in bile acid synthesis; b)the lack of a gallbladder to store a portion of the bile acids in the enterohepatic circulatory pool; and c) losses of bile acids into the large gut during each cycle of the enterohepatic circulation.