This study investigated the utility of systematically administering clonidine to detoxify opiate-dependent inpatients. Fifteen patients received a 0.1 mg dose of clonidine orally at 8:00 am, 12:00 noon, 4:00 pm, and at bedtime. A 0.1 mg dose was also administered as needed if any withdrawal signs were evidenced, but this additional dose was rarely needed after the second day of treatment. Night sweats were the only significant complaint reported. All 15 patients were successfully detoxified after ten days of treatment.
Caffrey, Dennis L. and Yoo, Tai P.
"Clinical Note: Use of Clonidine to Detoxify Opiate-Addicted Patients,"
Henry Ford Hospital Medical Journal
: Vol. 30
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol30/iss3/14