A hyperviscosity syndrome developed in two patients with rheumatoid arthritis. Analytic ultracentrifugation of the sera from one patient demonstrated 22S complexes. Intermediate, 22S, and 31S complexes were found in the second case. Platelet aggregometry and electron microscopy surveys of the platelet reactivity in one patient demonstrated inhibition of platelet reactivity caused by the presence of the high molecular weight complexes. These abnormalities, as well as the clinical bleeding, whole blood, and plasma viscosity, became normal after treatment. In vivo leukocytic function was studied with the Rebuck skin window technique, and phagosomal inclusions were observed in both the polymorphonuclear neutrophils and macrophages.
Lovy, Michael R.; Kranc, Mark C.; Bluhm, Gilbert B.; Riddle, Jeanne M.; and Stein, Paul D.
"Hyperviscosity Syndrome Complicating Rheumatoid Arthritis: Report of Two Additional Cases and Review of the Literature,"
Henry Ford Hospital Medical Journal
: Vol. 30
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol30/iss4/3