Linkage Data Excluding a Locus for Multiple Endocrine Neoplasia Type 2 Syndromes from the Distal Part of the Short Arm of Chromosome 11

Authors

Kenneth K. Kidd
Susan D. Kruger
Daniela S. Gerhard
Judith R. Kidd
David Housman
Joseph M. Gertner

Abstract

A study designed to identify the location of a gene for multiple endocrine neoplasia type 2 (MEN-2) is being performed using a single large family segregating for MEN-2A. Here we report our initial results using a set of DNA restriction fragment length polymorphisms spanning a 40 cM segment of the short arm of human chromosome 11. The locus for MEN-2 in this family is excluded from this entire region which includes an oncogene, c-Ha-ras-1, two hormone loci, insulin and parathyroid, and the five hemoglobin genes in the beta hemoglobin gene duster. This is the first exclusion of such a large continuous segment of the genome as a location for a gene for MEN-2. However, because genetic heterogeneity may exist for MEN-2, we cannot exclude the possibility that in some other kindred a locus in this region is responsible for MEN-2.

Recommended Citation

Kidd, Kenneth K.; Kruger, Susan D.; Gerhard, Daniela S.; Kidd, Judith R.; Housman, David; and Gertner, Joseph M. (1984) "Linkage Data Excluding a Locus for Multiple Endocrine Neoplasia Type 2 Syndromes from the Distal Part of the Short Arm of Chromosome 11," Henry Ford Hospital Medical Journal : Vol. 32 : No. 4 , 262-265.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol32/iss4/13