Chromosomes in Multiple Endocrine Neoplasia Type 2 Syndromes

Authors

Daniel L. Van Dyke
V. Ramesh BabuFollow
Charles E. Jackson

Abstract

In 19 patients from nine MEN-2A families, high-resolution C-banded chromosome studies have revealed a visible deletion within sub-band 20p12.2, yet no abnormality was observed in a 10th family. A deletion indistinguishable from that in MEN-2A was observed in five patients from three MEN-2B families but not in two other MEN-2B families. We found no abnormality in the entire karyotype of the four MEN-1 patients studied. These findings suggest that the mutation in most MEN-2 patients is a visible deletion in the short arm of chromosome 20.

Recommended Citation

Van Dyke, Daniel L.; Babu, V. Ramesh; and Jackson, Charles E. (1984) "Chromosomes in Multiple Endocrine Neoplasia Type 2 Syndromes," Henry Ford Hospital Medical Journal : Vol. 32 : No. 4 , 266-268.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol32/iss4/14