Central pontine myelinolysis is a demyelinating process that has occurred in association with rapid correction of hyponatremia. Presented here is the case of a patient who had adrenal insufficiency and who experienced signs of central pontine myelinolysis after rapid correction of severe hyponatremia (28 mEq/L of sodium administered in the first 24 hours, initial serum sodium level 97mEq/L). Sustained hyponatremia and the use of intravenous contrast material after hyponatremia correction are discussed as possible risk factors in the development of central pontine myelinolysis.
Brunner, John E.
"Central Pontine Myelinolysis in a Patient with Adrenal Insufficiency,"
Henry Ford Hospital Medical Journal
: Vol. 33
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol33/iss1/12