Henry Ford Hospital Medical Journal


John E. Brunner


Central pontine myelinolysis is a demyelinating process that has occurred in association with rapid correction of hyponatremia. Presented here is the case of a patient who had adrenal insufficiency and who experienced signs of central pontine myelinolysis after rapid correction of severe hyponatremia (28 mEq/L of sodium administered in the first 24 hours, initial serum sodium level 97mEq/L). Sustained hyponatremia and the use of intravenous contrast material after hyponatremia correction are discussed as possible risk factors in the development of central pontine myelinolysis.