The Clinical Usefulness of Measuring Apolipoproteins in Diabetic Patients: A Preliminary Report

Authors

J. David Fachnie
Janet McGill
Craig Foreback
Dorothy M. Kahkonen

Abstract

A commercial assay for apolipoproteins A-1 and B as well as total cholesterol, triglyceride, and high-density lipoprotein (HDL) cholesterol was applied to 12-hour fasted serum from 24 insulin-dependent and 19 noninsulin-dependent diabetic persons. Women with noninsulin-dependent diabetes mellitus (NIDDM) had the highest levels of total cholesterol and apolipoprotein B. Apolipoprotein B values fell within the normal range in all patients except the NIDDM females, where four of the ten (40%) samples were elevated. When apolipoprotein B was elevated, total cholesterol was also elevated, over 220 mg/dL. Apolipoprotein A-1 values fell within or above the normal range in all subjects, and a considerable discordance was observed between apolipoprotein A-1 elevations and HDL cholesterol elevations. The divergence between HDL cholesterol and apolipoprotein A-1 supports the altered composition of HDL in the diabetic persons studied. Further study should elucidate the clinical usefulness of apolipoprotein measurements in diabetic patients.

Recommended Citation

Fachnie, J. David; McGill, Janet; Foreback, Craig; and Kahkonen, Dorothy M. (1986) "The Clinical Usefulness of Measuring Apolipoproteins in Diabetic Patients: A Preliminary Report," Henry Ford Hospital Medical Journal : Vol. 34 : No. 2 , 113-116.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol34/iss2/11