D-Penicillamine-Induced Polymyositis Occurring in Patients with Rheumatoid Arthritis: A Report of Two Cases and Demonstration of a Positive Lymphocyte Stimulation Test to D-Penicillamine

Authors

Takayuki Matsumura
Takamichi Yuhara
Kazuhide Yamane
Ichiro Kono
Teizo Kabashima
Heihachiro Kashiwagi

Abstract

Two patients with erosive, seropositive rheumatoid arthritis developed polymyositis during treatment with D-penicillamine. In both patients the HLA tissue typing revealed the presence of DR4. The myopathy improved promptly after withdrawal of D-penicillamine and institution of prednisolone therapy. In one patient, hypersensitivity to D-penicillamine was demonstrated by a lymphocyte stimulation test. This is the first case of D-penicillamine-induced polymyositis in which T-cell proliferative response to D-penicillamine was demonstrated in vitro.

Recommended Citation

Matsumura, Takayuki; Yuhara, Takamichi; Yamane, Kazuhide; Kono, Ichiro; Kabashima, Teizo; and Kashiwagi, Heihachiro (1986) "D-Penicillamine-Induced Polymyositis Occurring in Patients with Rheumatoid Arthritis: A Report of Two Cases and Demonstration of a Positive Lymphocyte Stimulation Test to D-Penicillamine," Henry Ford Hospital Medical Journal : Vol. 34 : No. 2 , 123-126.
Available at: https://scholarlycommons.henryford.com/hfhmedjournal/vol34/iss2/14